TRIB3 and chronic kidney disease: Furthermore, in mouse CKD models derived from acute kidney injury (unilateral ureteral obstruction mice, 5/6 nephrectomy mice) and chronic metabolic disturbance-related CKD (db/db mice, apolipoprotein E [ApoE] KO with streptozotocin [STZ] administration mice), TRIB3 mRNA expression in the aorta was substantially higher than that in Sham or WT mice (Supplemental Figure 1, J–M).