Furthermore, in mouse CKD models derived from acute kidney injury (unilateral ureteral obstruction mice, 5/6 nephrectomy mice) and chronic metabolic disturbance-related CKD (db/db mice, apolipoprotein E [ApoE] KO with streptozotocin [STZ] administration mice), TRIB3 mRNA expression in the aorta was substantially higher than that in Sham or WT mice (Supplemental Figure 1, J–M). This evidence concerns the gene APOE and chronic kidney disease.