Although inflammatory effects appear to dominate in AngII-induced hypertension, with lesions exacerbated in cases of TGF-β neutralization (28), reduction of blood pressure with hydralazine nevertheless attenuates AngII-induced aortic inflammation, stiffening, and adventitial collagen deposition (36) and it prevented NE-induced dissection herein. This evidence concerns the gene TGFB1 and hypertensive disorder.