In addition to MBNL proteins, other RNA-binding proteins, including CUGBP and Elav-like family member 1 (CELF1), HNRNPA1, and the double-stranded RNA-binding protein Staufen 1 (STAU1), have been proposed to play a role in DM1 disease onset (12, 15, 33–37). The gene discussed is CELF1; the disease is myotonic dystrophy type 1.