NOS3 and open-angle glaucoma: Consistent with its role as a biomarker for primary open angle glaucoma (POAG) (46), we observed a significant increase in ELAM1 protein expression in the SC/TM region of Nos3-KO mice at P90 (2.2 ± 0.3, n = 7, Figure 5, A and B) compared with both C57BL/6J mice at P90 (1.0 ± 0.2, P = 0.0167, 1-way ANOVA with Tukey’s multiple-comparison test, n = 6) and Cre;Nos3fl/fl mice at P90 (1.0 ± 0.8, P = 0.0014, n = 16).