We observed lower levels of the Mitosox in the LCAD–/– cells as well as lower levels of thioredoxin reductase (TrxRD) and 4-Hydroxynonenal (4HNE), which are clear indicators of a blunted stress response in these cells (Supplemental Figure 7). Here, PRDX5 is linked to long chain acyl-CoA dehydrogenase deficiency.