To this point, compelling evidence indicates the critical role of NPRL2 in causing DNA damage and double-strand break (Ueda et al., 2006; Jayachandran et al., 2010; Ma et al., 2017) which can be used to trigger DC activation, antigen presentation, and priming of tumor-specific CD8+ T cells in the TME. This evidence concerns the gene CD8A and neoplasm.