In the amygdala, the difference between 3xTg-AD (saline treated) and WT (saline treated) group was apparent because of the significant increase of GFAP in 3xTg-AD (saline treated) group (p = 0.04) compared to WT (saline treated) group (Fig. 5.Q). The gene discussed is GFAP; the disease is Alzheimer disease.