AIF1 and Alzheimer disease: Immunohistochemical staining for Iba1, a marker of both activated and resting microglia and macrophages, revealed an increased number of activated microglia in the hippocampi (p < 0.0001), amygdalae (p < 0.001), and cortices (p = 0.0002) of 10-month-old saline-treated 3xTg-AD mice compared to the saline-treated WT group.