PGVs affecting only the tumor-suppressor protein p14(ARF) are associated with nerve sheath tumors, while those affecting both p16 and p14 are associated with pancreatic cancer, atypical nevi, melanoma, brain tumors, gallbladder tumors, thyroid cancer, and sarcomatous nerve sheath tumors [25]. The gene discussed is CDKN2A; the disease is thyroid cancer.