GSEA of canine and human DEGs using IMMUNESigDB revealed greater than 60% overlap (CD4: 670/899, CD8: 77/121, DC: 281/404, Monocyte: 187/250) between canine and human enriched pathways, suggesting conserved transcriptomic responses to tumor infiltration (Supplemental Fig. 11, Supplemental Data 10). Here, CD4 is linked to neoplasm.