SH2D3A and infection: Furthermore, partial loss of NSP1, which correlates with a lower viral load and less severe symptoms of infection in SARS-CoV-2-infected patients, or of ORF8, which has been reported as associated with milder infection in humans, were also associated with attenuated phenotypes (Lin et al., 2021; Ueno et al., 2024; Young et al., 2020).