In contrast to in vitro observations, in vivo overexpression of TRIB3 significantly enhanced hepatoma cell proliferation and EMT, as evidenced by increased Ki67 expression in hepatoma cells and alterations in vimentin and E‐cadherin levels under long‐term sorafenib treatment (Figure 3E,F; Figure S3B, Supporting Information). This evidence concerns the gene CDH1 and hepatocellular carcinoma.