Notably, the chemokine receptors CXCR1/2 play a central role in facilitating neutrophil migration from the peripheral blood to local tissues.[31, 32, 33] Intriguingly, leveraging single‐cell sequencing data from human HCC tumors, we discovered that hepatoma cells expressing TRIB3 were the predominant source of CXCR1/2 ligands, including CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Figure S5A, Supporting Information). This evidence concerns the gene CXCL5 and hepatocellular carcinoma.