Pathway related to the unfolded protein response (UPR) was intensively enriched in hepatoma cells treated with sorafenib, which was further confirmed by Gene Set Enrichment Analysis (GSEA), implicating a potential involvement of endoplasmic reticulum (ER) stress in sorafenib‐mediated TRIB3 induction (Figure 2A,B). Here, TRIB3 is linked to hepatocellular carcinoma.