Knockout of ABCG5/G8 (ABCG5/G8‐KO) does not completely prevent CGD in LD‐fed mice, whereas reducing gallbladder MUC1 levels significantly decreases the incidence of CGD, regardless of changes in biliary CSI.[9] This suggests that the upregulation of ABCG5/G8 and the activation of the FXR‐FGF15/19‐Cyp7a1 signaling pathway may not be the primary drivers of CGD pathogenesis. This evidence concerns the gene ABCG5 and chronic granulomatous disease.