SP1 and metabolic dysfunction-associated steatotic liver disease: The transactivation of the MUC1 gene was demonstrated to be regulated by the transcription factor Sp1, which is also a potential risk factor in the progression of NAFLD.[20] We analyzed MUC1 promoter sequences from various species using the JASPAR transcription factor binding profile server[21] and identified eight potential Sp1 consensus binding sites within the mouse MUC1 promoter region (Figure 4A; Table S6, Supporting Information).