The gallbladder MUC1 deficiency also reduced gallbladder MUC5ac expression in WD‐fed micecC70‐KO (Figure S5B, Supporting Information), which was consistent with prior studies.[9, 11] Additionally, overexpression of MUC1 (MUC1‐OE) after intraperitoneal (i.p.)injection of adeno‐associated viral vector (AAV) increased gallbladder MUC1 and MUC5ac (MUC1·5ac) levels and CGD susceptibility in miceWT fed either a WD for 8 weeks or a LD for 3 weeks (Figures S4D and S5C,D; Tables S1E,F, Supporting Information). Here, MUC5AC is linked to chronic granulomatous disease.