Long noncoding RNA POU3F3 (Linc‐POUF3F3) has been widely investigated and characterized as an oncogenic Linc‐RNA in many types of cancers.[18] Our previous work demonstrated that Linc‐POUF3F3 enhances cancer cell proliferation, migration and invasion in NSCLC by downregulating microRNA‐30d‐5p.[19] Linc‐POUF3F3 has been also found to contributes to tumorigenesis by epigenetically modulating POU3F3 gene expression.[20] It is of great interest to evaluate whether the POU3F3 protein participate the cancer development progression. This evidence concerns the gene POU3F3 and cancer.