High levels of RNase1 in tissues from patients with cancer were significantly and positively correlated with the expression of ICs, including CD274 (PD‐L1), CTLA4, HAVCR2 (TIM‐3), PDCD1 (PD‐1), LAG‐3, PDCD1LG2 (PD‐L2), and T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), in various cancers, such as HNSC, breast invasive carcinoma (BRCA), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC), colon adenocarcinoma (COAD), and esophageal carcinoma (ESCA) (Figure 3C). Here, RNASE1 is linked to squamous cell lung carcinoma.