Our earlier studies have shown that RNase1 expression is higher in breast and liver cancer tissues compared to normal tissues.[6, 11] Through a differential gene expression analysis in Tumor, Normal, and Metastatic tissues (TNM plot analysis),[17] we revealed that hepatocellular carcinoma (HCC), melanoma, esophageal cancer, and ovarian cancer tissues express higher levels of RNase1 than normal tissues (Figure 3A). This evidence concerns the gene RNASE1 and liver cancer.