Since high‐RNase1 expression enriches T‐cell exhaustion signatures in patients with HNSC, breast cancer, and HCC (Figure 3D), we further performed correlation analysis between the gene expression of these 18 proteins and effector T‐cell signatures in HNSC, breast cancer, and HCC patient samples by using the GEPIA2 database.[22] STAT1 and ITGB2 out of the 18 candidates were identified to show a significant positive correlation with effector T‐cell signatures in these three cancer types (Figure 6C). This evidence concerns the gene RNASE1 and cancer.