To this end, we found that STAT1 in HNSC, breast cancer, and HCC patient tissues displayed a positive correlation with RNase1‐related effector cytokine signatures according to the analysis of TCGA dataset by using the GEPIA2 database (Figure 6D), including IL‐2, INF‐γ, IL‐6, and GM‐CSF which have been shown to be repressed by RNase1 in activated T cells (Figure 1 and Figure S1, Supporting Information). Here, IL6 is linked to hepatocellular carcinoma.