Our earlier studies have shown that RNase1 expression is higher in breast and liver cancer tissues compared to normal tissues.[6, 11] Through a differential gene expression analysis in Tumor, Normal, and Metastatic tissues (TNM plot analysis),[17] we revealed that hepatocellular carcinoma (HCC), melanoma, esophageal cancer, and ovarian cancer tissues express higher levels of RNase1 than normal tissues (Figure 3A). This evidence concerns the gene RNASE1 and melanoma.