Among those diagnosed with LGS, 14 patients had an underlying structural etiology, and six patients presented with pathogenic variants in genes including COL4A2, GPHN, HUWE1, and SZT2, a 2q37 deletion, and a chromosomal aberration in chromosome 9 (each n = 1). The gene discussed is HUWE1; the disease is Lennox-Gastaut syndrome.