CXCR3 and HIV-1 infection: Our data suggest that both CXCR3− and CXCR3+ cTfh may be progeny of the activated CXCR3+ Tfh during AHI, an observation that is in line with a recent study which showed that both CXCR3− and CXCR3+ cTfh have shared clonotypes with CXCR3+ tonsillar Tfh (81), and may help explain disparate findings of correlations between neutralizing antibody production and CXCR3− versus CXCR3+ cTfh frequencies during HIV-1 infection (82, 83).