TRPM4 and neoplasm: That TRPM4 and NDUFB1 were both found to be predictive of both Acetalax and bisacodyl activity in cell lines (Fig. 6) and were also found to significantly correlate with PDX tumor response to Acetalax (Fig. 3; Supplementary Fig. S5) and have differential expression in responders versus resistant PDXs (Fig. 5) indicates functional concordance between the cell line and PDX models.