Conversely, FLT3-ITD;NPMc mice were generated by intercrossing a knockin mouse carrying a human ITD within the juxtamembrane (JM) domain of exon 14 of the murine Flt315 with a conditional knockin mouse model of the most common form of NPM1c mutation, type A.16 Both animal models develop AML manifested as increased white blood cell counts and splenomegaly (Figures S1A and S1B). This evidence concerns the gene FLT3 and acute myeloid leukemia.