EIF4E and acute myeloid leukemia: eIF4A1 is the eIF4F complex helicase responsible for unwinding stable mRNA secondary structures to allow ribosome scanning and cap-dependent translation.52 eIF4A1 was 1 out of 6 proteins detected as transferred from BMSCs to AML blasts via EVs (see Figure 6D; Table S8) and increased in EVs from coculture, compared with AML monoculture (see Figure 6C).