EIF4A1 and acute myeloid leukemia: The marine natural product pateamine A (PatA) stabilizes eIF4A’s interaction with mRNA and prevents its release, inhibiting cap-dependent translation.53 The PatA analog des-methyl,des-amino PatA (DMDA-PatA; hereon eIF4Ai [eIF4A inhibitor]) displays potent anticancer activity.54 As expected, eIF4Ai pre-treatment inhibited translation and induced AML apoptosis (Figures S5B–S5E).