SPG1/L1CAM, the gene encoding the transmembrane multifunctional neuronal adhesion molecule L1, is associated with the neurodevelopmental disorders and different process of brain development including differentiation of adult‐born hippocampal neurons, axonal, and dendritic arborization and neuronal migration [77, 78, 79, 80]. The gene discussed is L1CAM; the disease is neurodevelopmental disorder.