To investigate the expression profile of HSP genes during cortical development, we used the published database GSE38805 [60] and GSE65000 [61] to monitor the transcriptome expression profiles of SPG4/SPAST and SPG11/KIAA1840, which are the primary causes of AD HSP and AR HSP, respectively, across various regions of embryonic brain tissues in humans and mice. Here, SPG11 is linked to hereditary spastic paraplegia.