SPAST and Alzheimer disease: To investigate the expression profile of HSP genes during cortical development, we used the published database GSE38805 [60] and GSE65000 [61] to monitor the transcriptome expression profiles of SPG4/SPAST and SPG11/KIAA1840, which are the primary causes of AD HSP and AR HSP, respectively, across various regions of embryonic brain tissues in humans and mice.