Consistently, IHC staining of xenograft tumor tissues revealed that the knockdown of RPAP2 rescued the growth‐promoting effect of FBXW7 deprivation, as reflected by decreased staining of Ki67, a marker of cell proliferation, and increased staining of Cleaved‐Caspase‐3, a marker of apoptosis (Figure 7F). This evidence concerns the gene RPAP2 and neoplasm.