FBXW7 is primarily recognized as a tumor suppressor because of its ability to ubiquitylate and degrade various oncoproteins such as c‐MYC, c‐JUN, Cyclin E, NOTCH1, and MCL‐1.[9] Unexpectedly, we observed elevated FBXW7 protein levels in HCC tissues from 13 out of 15 patients compared to their corresponding adjacent non‐tumorous tissues (Figure S6I, Supporting Information). The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.