FBXW7 and hepatocellular carcinoma: Interestingly, several studies reported lower FBXW7 levels in HCC tissues compared to normal tissues at both the mRNA[26] and protein levels.[26, 27] Therefore, it is an open question as to how mechanistically both levels of FBXW7 mRNA (Figure S6J, Supporting Information) and protein (Figure S6I, Supporting Information) were higher in human HCC tissues, which is certainly an interesting subject for future investigation.