Similarly, the phosphorylation of p38, a priming kinase for the CPD motif of RPAP2 (Figure 4), was decreased in the majority of HCC cases, with 9 HCC samples showing down‐regulation, 5 showing up‐regulation, and 1 displaying no change compared to their corresponding adjacent non‐tumorous tissues (Figure S6I, Supporting Information). This evidence concerns the gene RPAP2 and hepatocellular carcinoma.