To this end, we first examined the levels of RPAP2 in multiple HCC cell lines and found that RPAP2 protein levels were higher in Huh7 and JHH7 cells, lower in Hep3B and PLC/PRF/5 cells, and nearly undetectable in SNU‐423 cells (Figure S6F, Supporting Information). This evidence concerns the gene HSPG2 and hepatocellular carcinoma.