FBXW7 is primarily recognized as a tumor suppressor because of its ability to ubiquitylate and degrade various oncoproteins such as c‐MYC, c‐JUN, Cyclin E, NOTCH1, and MCL‐1.[9] Unexpectedly, we observed elevated FBXW7 protein levels in HCC tissues from 13 out of 15 patients compared to their corresponding adjacent non‐tumorous tissues (Figure S6I, Supporting Information). This evidence concerns the gene NOTCH1 and neoplasm.