Notably, in MM, a cancer phenotype not utilized to generate the optimized analysis parameter values and derived from adult samples, ImmunoTar identified targets previously reported by other groups such as ITGA4, ITGB7, and FLVCR1, confirming the robustness of our methodology and the applicability of our multi-cancer parameter values highlighting that while targets across different cancers may vary, the underlying characteristics of effective targets are consistent. Here, ITGB7 is linked to Miyoshi myopathy.