Collectively, these findings show that in the setting of hypercholesterolemia, SMC-Abca1/Abcg1 deficiency induces bladder wall SMC lipid accumulation, bladder wall thinning, loss of SMC markers, and an increase in Lgals3+ SMCs, macrophage-like, and fibroblast-like cells. The gene discussed is ABCA1; the disease is familial hypercholesterolemia.