Four potential target genes associated with T2DM (Jun, p65, NOS3, and PDE5A) were firstly bioinformatically screened by Zhang L. et al. (2021); then it was verified in animal experiments that ICA can treat high-fat-high-glucose (HFHG) diet combined with STZ-induced DCM rats, and the results showed that ICA improved blood sugar, HW/BW, intracellular Ca2+ hyperactivities and function in myocardium in DCM rats. Here, PDE5A is linked to familial dilated cardiomyopathy.