In type 2 diabetes mellitus (T2DM), the activation of inflammatory pathways not only leads to the formation of an inflammatory microenvironment inside the islet, which then damages the insulin secretion function of beta cells and causes insulin resistance, but also plays an important role in the occurrence and development of diabetic complications (Lontchi-Yimagou et al., 2013). The gene discussed is INS; the disease is type 2 diabetes mellitus.