Similarly, bone morphogenic protein 6 (Bmp6), which is part of both the ‘TGF-beta signaling pathway’ and ‘cytokine-cytokine receptor interaction’, was elevated in the 3xTg-AD vehicle group compared to the WT group and showed a reduction after RA-PR058 treatment (Supplementary Figure S2B, C). This evidence concerns the gene BMP6 and Alzheimer disease.