CALCR and early-onset autosomal dominant Alzheimer disease: working on Pmp21, the Cpn homologue of Ctr PmpD, showed that the hMW oligomers formed by Pmp21 exhibit an amyloid-like character (Luczak et al., 2016) that is very similar to the amyloid fibrils formed by Aβ42, a protein fragment which plays a vital role in Alzheimer’s disease (Gu and Guo, 2013).