Finally, gene expression analysis of tumor tissues reveals that ST2-deficient mice exhibited increased overall levels of IL-4 and IL-6 (cytokines associated with the Th2-immune response, and with the accumulation of myeloid-derived suppressor cells40), as well as of the immunosuppressive cytokine IL-10, while iNOS remain unaltered (Supplementary Figure S12). This evidence concerns the gene IL4 and neoplasm.