In experimental stroke, IL-33 activation resulted in an improved outcome characterized by reduced glial scarring and a weakened T-cell response.23 Tumors exhibit numerous resemblances with tissue damage, such as inflammation, tissue remodeling, and cell migration.24 Given similarities between the mechanisms of wound healing and the development of tumors, we asked whether IL-33 participates in shaping the glioma microenvironment. The gene discussed is IL33; the disease is central nervous system cancer.