We aimed to determine the mRNA expression levels of RIPK1 in two murine tauopathy models (AAV-TAUP301L and Tg- TAUP301S) and compare them with what occurs in humans with primary (PSP) and secondary (AD) tauopathies, to establish whether abnormal TAU protein is linked to alterations in RIPK1 across both animal models and human tauopathy patients. Here, RIPK1 is linked to supranuclear palsy, progressive, 1.