Finally, to assess the relevance of RIPK1 in human TAU pathology, we analyzed post-mortem hippocampal biopsies from four asymptomatic control donors, four AD patients with neurofibrillary tangles (a secondary tauopathy) (Lastres-Becker et al., 2014), and five patients with PSP, a 4R-tauopathy. This evidence concerns the gene RIPK1 and tauopathy.