As recently shown, 4-OI can enhance oncolytic virotherapy by suppressing antiviral immunity in cancer cells through the modification of cysteine residues in the mitochondrial antiviral signalling (MAVS)-IKKβ pathway proteins.99 The viral replication of influenza A, a positive-strand RNA (−ssRNA) virus, occurs within the nucleus of the host. Here, MAVS is linked to cancer.