Although some studies have suggested that NF-κB and PI3K inhibitors display anti-inflammatory activity during influenza infection, further investigation is necessary to understand the roles of NF-κB and PI3K pathways in cytokine expression regulation on the U937 model (Lamichhane et al., 2018; Lu et al., 2011; Ehrhardt et al., 2013). This evidence concerns the gene NFKB1 and influenza.