↑ delays the activin pathwayattenuates the erythroid differentiation reduces the formation of CFU-E and BFU-Ereduces angiogenesis and prevents the migration of cancerinhibits heme biosynthesis accumulation of succinate transition defect blocks the heme synthesis↓ induces the activin A pathwayenhances EV-mediated B cell increases the survival rate of B cell acute lymphoblastic leukemiaenhances terminal erythroid differentiation (erythropoiesis)induces B cell enhances the IgA secretion prevents infection. This evidence concerns the gene INHBE and infection.