↑ suppress the expression of c-Mybblocks cell cycle progression (tumor suppressor of CLL)inhibits erythropoiesis (differentiation of erythroid and myeloid) ↑ HbF expression ameliorates the severity of sickle cell disease and β-thalassemia↓ enhances expression of IL-7 receptor (IL7R) blocks the B-cell maturation accumulation of B1 and T cells development of CLL. Here, IL7R is linked to sickle cell disease.