↑ related to the increased proliferation of megakaryocytic cells (c-Myb) inhibits early development of B cellsincrease platelet formationpromote caspase-3 activation leads to apoptosis in pathologic cells (B cell lymphoma)↓ related to deletion of c-Myb (terminal erythropoiesis)B1 cell proliferation IgM ↑ enhances humoral immune responseinteracts with FOXP1 restrict the activity of caspase-3 reduces apoptosis and influences the cell growth B cell lymphoma. The gene discussed is MYB; the disease is B-cell non-Hodgkin lymphoma.