Targets are enriched in 147 pathways, and the top 20 entries were considered based on enrichment score (Table S3, Supplementary file 1, Extended data70), as shown inFigure 3 and4, which comprise the TGF-β signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, FoxO signaling pathway, and TNF signaling pathway in IPF (Figure S1-S5, Supplementary file 1, Extended data70). The gene discussed is AKT1; the disease is idiopathic pulmonary fibrosis.