Phytomolecules from the rhizomes ofZingiber zerumbet impact core targets TGF-β1, EGFR, MMP9, TNF-α, and MMP2 in IPF are expected to release immediate injury mediators, mesenchymal transition to secret ECM, fibroblast proliferation, and differentiation at various stages of idiopathic pulmonary fibrosis progression. This evidence concerns the gene TNF and pulmonary fibrosis.