The FoxO signaling pathway, which is connected to numerous other important pathways including PI3K/AKT, MAPK, TNF signaling pathways, and EGFR tyrosine kinase inhibitor resistance pathway, whereas the TGF-β signaling pathway has been profoundly enriched and is the pathway where phytomolecules interrupt the IPF progression along with FoxO signaling pathway. Here, TNF is linked to idiopathic pulmonary fibrosis.