CLDN8 and hepatocellular carcinoma: Wang W et al. reported that the CLDN family is closely related to EMT in hepatocellular cancer (Wang et al., 2024), as well, Chang JW et al. show that CLDN1 promoted invasive phenotypes by upregulating epithelial-to-mesenchymal transition (EMT) in HNSC (Chang et al., 2022), although the relationship between CLDN20, CLDN8, etc., and EMT is poorly reported.