Further database exploration revealed that in oral and tongue tumors (TNMplot), we found that CCL26 had a significant correlation phenotype with four classical markers of EMT: among them, it was negatively correlated with E-cad (R = −0.34, P < 0,05), and significantly correlated with N-cad (R = 0.34, P < 0,05), VIM (R = 0.44, P < 0,05) and SNAI2 (R = 0.34, P < 0,05) were positively correlated (Figures 4I–M), suggesting that CCL26 may affect the invasive phenotype of oral cancer cells through mesenchymal transformation. The gene discussed is SNAI2; the disease is lip and oral cavity carcinoma.