RHO and retinitis pigmentosa 1: A study using RP patient-derived retinal organoids, found that these organoids exhibited photoreceptor dysgenesis, increased RHO mRNA expression, and mislocalisation of the rhodopsin protein within rod photoreceptors (Kandoi et al., 2024) Additionally, treatment with the small molecule Photoregulin 3 partially corrected the mislocalisation of rhodopsin by targeting NR2E3, an RHO upstream regulator.