Notably, the OR value for the association between hs-cTnT and PAD in diabetic patients with chronic kidney disease is over twice that of diabetic patients without chronic kidney disease, consistent with the changes in OR values observed in the multivariate regression analysis in 2.2, confirming that chronic kidney disease strongly interferes with the association between hs-cTnT and lower limb disease in diabetic patients aged 40 and above in the United States. The gene discussed is TNNT2; the disease is peripheral arterial disease.