In metastatic ccRCC, commonly expressed immunohistochemical markers include CD10, PAX-2, PAX-8, human kidney injury molecule-1 (hKIM-1), renal cell carcinoma monoclonal antibody (RCCma), von Hippel–Lindau (VHL) tumor suppressor gene products, EMA, E-cadherin, and S-100 protein (9, 10). Here, PAX8 is linked to hereditary clear cell renal cell carcinoma.