BACE1 and Senile plaques: Amyloid beta, which makes up the majority of senile plaques, is assumed to play a key role in the death of neurons and may play a role in synapse and neural network dysfunction as well as cognitive impairment in AD.58,59 In the present study, phytocompounds were predicted to target GSK3B, MAOA, BCHE, ACHE, BACE1, LGMN, and GRIN1 and found to regulate neurotransmitter levels, cell communication, signalling, cellular response to amyloid-beta, learning, amyloid precursor protein metabolic process, nervous system process, regulation of synaptic plasticity and neuron apoptotic process.