At present, there are still some gaps in the research on the role of UCK2 in immune interaction and stemness in different cancers, UCK2, as an enzyme involved in pyrimidine nucleotide metabolism (17), has been gradually recognized for its role in tumor development, but its interaction with the immune system and the specific mechanism of action in different types of cancer have not yet been fully revealed. The gene discussed is UCK2; the disease is cancer.