Recently, many studies have shown that in hepatocellular carcinoma, the gene UCK2 is closely related to the immune microenvironment (43, 64), and it can promote normal and malignant T cell proliferation (62), UCK2 is closely related to LIHC survival, we believe that it may affect the tumor immune microenvironment and inhibit the activity of T cells, thus affecting the overall survival rate of patients. The gene discussed is UCK2; the disease is neoplasm.