The CD56+ cells were significantly more abundant in tumor, stroma and total in the Io+Chemo group compared with Chemo (density: tumor, p=0.002, stroma, p=0.007, total, p=0.000; percentage: tumor, p=0.000, stroma, p=0.009, total, p=0.000; H-score: tumor, p=0.001, stroma, p=0.000, total, p=0.000). The gene discussed is NCAM1; the disease is neoplasm.