Collectively, preNeut, immNeut, and matNeut neutrophils correlated with relatively naïve gene signatures, whereas Neut_Ifit1presented quiescent mature neutrophil features, preparing for potential infectious threats, and Neut_Gngt2 and Neut_Cd14 acted as activated/mobilized mature neutrophils post‐stroke. Here, GNGT2 is linked to Stroke.