ITGAX and Alzheimer disease: Consequently, microglia can play either detrimental roles in exacerbating ischemic injury or beneficial roles in neurogenesis, angiogenesis, and neuroprotection.[83, 84, 85, 86] In this study, we successfully defined 8 microglial subclusters, and identified DAM subtype in stroked mice, which was recognized for its protective roles in AD.[68] Intriguingly, DAM also presented immature transcriptional features in RNA velocity analysis, showing a similar gene expression pattern to the CD11c+ P7 youth‐associated microglial subtype, as reported by Silvin et al.[66]