The Cl− transmembrane transporter modulates WNK1‐mediated SPAK/OSR1‐CCCs activation and promotes the survival and M2‐like polarization of microglia in ischemic stroke.[72] Following stroke, microglial subtypes were enriched with genes associated with cell migration, chemotaxis, and biogenesis of organelles, in contrast to genes enriched with antigen processing or cell‐mediated immunity functions in sham mice, indicating an active transcriptomic and functional switching of microglia after stroke (Figure S12, Supporting Information). Here, WNK1 is linked to ischemic stroke.