PTPRC and stroke disorder: To better decode the gene expression alterations of immune cells in the brain post‐stroke and delineate their precise tissue origins, we conducted single‐cell RNA sequencing (scRNA‐seq) of sorted CD45+ cells from brain and potential distant origins for CNS‐infiltrated immune cells, including CBM, femur bone marrow (FBM), and peripheral blood mononuclear cells (PBMCs).