Interestingly, in response to DMM injury, LG/J mice develop robust synovial and meniscal calcification, correlated with SNPs relating to angiogenesis, bone metabolism/calcification, arthritis, and ankylosing‐spondylitis and gene transcripts of Aff3, Fam81a, Syn3, and Ank (Rai et al. 2015). This evidence concerns the gene SYN3 and arthritic joint disease.