Moreover, we considered a role for TGFβ1 in the suppression of CD8+ T cell differentiation, but our recent demonstration that D5.1G4 melanoma does not secrete this immunosuppressive cytokine [25] suggests that this mechanism is not responsible for the failure of anti‐tumor CD8+ T cells to acquire effector function in our model. This evidence concerns the gene TGFB1 and neoplasm.