TTYH3 and hepatocellular carcinoma: TTYH3 encodes high-conductivity chloride ion channels activated by Ca.2+27 Emerging evidence indicates that TTYH3 is aberrantly expressed in diverse cancers and functions substantially in tumor onset and progression.7–9,26 For instance, TTYH3 is upregulated in bladder cancer7 and hepatocellular carcinoma,8 the knockdown of which could suppress tumor progression.