Recent research has identified chloride channels as promising targets for therapeutic interventions in cancer metastasis.25 TTYH3, a large conductance chloride channel, plays crucial roles in the development of diverse cancers7–9,26 and has reportedly been highly expressed in NSCLC.11 Hence, we delved into the function and mechanism of TTYH3 in NSCLC metastasis. This evidence concerns the gene TTYH3 and non-small cell lung carcinoma.