TTYH3 and non-small cell lung carcinoma: Also, we analyzed the expressions of EMT-related proteins (E-cadherin, N-cadherin, Vimentin, and Snail) as epithelial-mesenchymal transition (EMT) is indispensable for tumor progression and metastasis.24 Here, epithelial indicator E-cadherin was dramatically augmented in NSCLC cells following TTYH3 knockdown, while mesenchymal indicators N-cadherin, Vimentin, and Snail were reduced (Figure 1g).