We also found that fibroblast growth factor 5 (OR 1.072 per SD increase in concentration; 95% CI 1.046–1.099; p < 0.001), interleukin‐2 receptor subunit β (OR 1.072 per SD increase, 95% CI 1.005–1.143; p = 0.036), and tumour necrosis factor (OR 1.089 per SD increase, 95% CI 1.030–1.152; p = 0.003) had causative effects, increasing the risk of AF. The gene discussed is FGF5; the disease is atrial fibrillation.