On the other hand, enforced expression of FOXO3a in PANC-1/GEM cells decreased the LDHA expression (Fig. 4C), CSC phenotypes (Supplementary Fig. 9B), tumour initiating capacity (Supplementary Table 4) and suppressed gemcitabine resistance (Fig. 4d and Supplementary Fig. 9C, D,E); further abolishment of miR-4259 by anti-miR-4259 significantly restored the effects of FOXO3a in PANC-1/GEM cells (Fig. 4C, D; Supplementary Fig. 9B and Supplementary Table 4). The gene discussed is LDHA; the disease is neoplasm.