In both the CLL and FL cohorts, the percentage and absolute number of NK cells with an immunophenotype positive for the expression of CD45RA, CD27 and CD279 and negative for CD 57 increased after 2 doses of vaccination (p = 0.03 and p = 0.0079, respectively; Fig. 2E). Here, CD27 is linked to B-cell chronic lymphocytic leukemia.