Independent of the vaccine response and therapeutic regimen received, in FL patients, the percentage and absolute number of central memory CD8+ CD57dim CD279+ T cells were weakly increased 15 days after the first dose (p = 0.05) and remained high after the second dose, which was significantly greater than the corresponding measure in CLL patients (p = 0.016) (Fig. 2D). The gene discussed is PDCD1; the disease is B-cell chronic lymphocytic leukemia.