CD274 and head and neck squamous cell carcinoma: When HNSCC cell lines were grown in the presence of both rFab’ and Cis-Pt the closure of wound was significantly delayed compared to Cis-Pt alone (24 h: FaDu wound closure anti-PD-L1 rFab’+ Cis-Pt 12% compared to Cis-Pt alone 65%; SCC-011 wound closure anti-PD-L1 rFab’+ Cis-Pt 7% compared to Cis-Pt alone 19%; 48 h: FaDu wound closure anti-PD-L1 rFab’+ Cis-Pt 43% compared to Cis-Pt alone 83%; SCC-011 wound closure anti-PD-L1 rFab’+ Cis-Pt 29% compared to Cis-Pt alone 33%) (Fig. 10C).