CD274 and head and neck squamous cell carcinoma: Interestingly, anti-PD-L1 rFab’ was able also to significantly decrease number (FaDu 40%; SCC-011 40%), size (FaDu 37%; SCC-011 79%) and viability (FaDu 30%; SCC-011 27%) of HNSCC spheroids demonstrating its efficacy on 3D models (Fig. 8A, B).