CREB1 and Leber congenital amaurosis: The results obtained showed that LCA induced a significant increase in phospho-cAMP response element-binding (CREB) (Ser 133) in LCA + LPS group compared to LPS (LPS vs LCA + LPS *p < 0,05), a key factor in the maintenance of synaptic changes such as dendritic spines (Ben Zablah et al. 2021).