IL6 and inflammation: Previous studies have reported that elevated levels of Tenericutes are associated with chronic gut inflammation and are directly linked to increased expression of IL-6 in the colonic environment.85 Interestingly, we show that MIIST305-treated animals display a significantly reduced concentration in colonic IL-6 levels at 6 DPI, consistent with the diminished levels of mucosal Tenericutes compared with Vehicle-treated animals.