Group 3 and Group 4 showed higher expression of Hmga2, which has been reported to regulate EMT programs during tumor progression (LaFave et al, 2020; Dost et al, 2020; Winslow et al, 2011; Naranjo et al, 2022) (Figs. 1F and EV1J). Here, HMGA2 is linked to neoplasm.