MAPT and Alzheimer disease: In this study, acute mouse hippocampal slices were incubated in identical concentrations of recombinant tau peptides covering the STA core region identified in this study (the ~aa 258–368 STA core), the ~aa 302–368 AD fibril core identified previously by cryo-EM, N terminus (aa 1–224) and C terminus (368–441) control peptides contained in the fuzzy coat peptides or in control buffer (artificial CSF (aCSF)) (Fig. 5a) for 1 h before electrophysiological recording.